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2017 Fiscal Year Final Research Report

Effects of DAMPs from cancer cells exposed to radiation on the properties of cancer cells

Research Project

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Project/Area Number 15K09985
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionHirosaki University

Principal Investigator

Yoshino Hironori  弘前大学, 保健学研究科, 助教 (10583734)

Project Period (FY) 2015-04-01 – 2018-03-31
Keywordsダメージ関連分子パターン / 放射線曝露細胞由来馴化培地 / 放射線 / 放射線抵抗性 / Nrf2 / 細胞移動能
Outline of Final Research Achievements

In the present study, we investigated the effects of damaged-associated molecular patterns (DAMPs) from X-irradiated cancer cells on the properties of cancer cells using irradiated cell conditioned medium (ICCM) containing DAMPs. The lung cancer cells pre-treated with ICCM from X-irradiated lung cancer cells were resistant to X-ray irradiation-induced cytotoxicity compared with non-treated control. Furthermore, the treatment with ICCM attenuated the X-ray irradiation-induced decrease in the lung cancer cell migration. Considering these results, there is a possibility that DAMPs contained in ICCM impairs the anti-cancer effects by radiation therapy.

Free Research Field

放射線生物学

URL: 

Published: 2019-03-29  

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