Safety and Effectiveness of Induction Chemotherapy Followed by Brachytherapy for Thick Oral Cancer

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09990
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: YOSHIMURA Ryoichi 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (40302864)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 口腔癌 / 導入化学療法 / 小線源治療

Outline of Final Research Achievements

To improve the treatment results of brachytherapy for thick oral cancer, we started this study of induction oral-chemotherapy using TS-1 followed by low-dose-rate brachytherapy. The treatment protocol consisted of 1 or 2 cycles of the TS-1 regimen (80-120 mg/day) according to a 2-weeks-on/1-week-off schedule followed by brachytherapy using low-dose-rate Ir-192 pins or Au-198 grains. The primary endpoint was the rate of complications, and the secondary endpoints were the local control rate and the rate of secondary cervical lymph node metastasis.
Between August 2015 and June 2017, 16 patients were enrolled. Although a few patients suffered from renal dysfunction, hepatic dysfunction, severe fatigue, or dermatitis by TS-1, the incidence of complications due to brachytherapy did not increase. The local control rate was the same as that in past reports. However, the rate of cervical lymph node metastasis was correlated with the number of cycles of the TS-1 regimen.

Free Research Field

放射線腫瘍学