Analysis of association between allo-immune response and FOXP3 polymorphism in organ transplantation

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10026
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Hiroshima University
• Principal Investigator: TANAKA Yuka 広島大学, 医歯薬保健学研究科(医), 准教授 (90432666)
• Co-Investigator(Kenkyū-buntansha): 大段 秀樹 広島大学, 医歯薬保健学研究科(医), 教授 (10363061)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 制御性T細胞 / 拒絶反応 / 遺伝子多型

Outline of Final Research Achievements

Regulatory T cells expressing the transcription factor Foxp3 are essential for immune homeostasis. This study investigated the impact of FOXP3 SNPs on the severity of ACR in liver transplant (LT) recipients.　We did not find any statistical association between the FOXP3 SNPs genotype frequencies and the incidence of ACR. However, significantly higher incidence of SRAR was observed in LT patients with the FOXP3 rs3761548 A/C+A/A genotype than in those with C/C genotype. The total dose of intravenous methylprednisolone used for ACR treatment was significantly higher in the rs3761548 A/C+A/A genotype than that in the C/C genotype. This fact suggests that the immunosuppression regime and/or anti-ACR treatment regimen should be adjusted on an individual basis by identifying FOXP3 SNPs, implying a need for personalized medicine in the field.

Free Research Field

移植免疫、腫瘍免疫