The establishment of breast navigation surgery using Si-PM based intraoperative PET system

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10045
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Tohoku University
• Principal Investigator: Watanabe Gou 東北大学, 大学病院, 講師 (70451573)
• Co-Investigator(Kenkyū-buntansha): 伊藤 正敏 東北大学, サイクロトロン・ラジオアイソトープセンター, 名誉教授 (00125501) ; 石田 孝宣 東北大学, 医学系研究科, 教授 (00292318) ; 渡部 浩司 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (40280820) ; 大内 憲明 東北大学, 医学系研究科, 客員教授 (90203710)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 乳癌 / 乳房温存手術 / PEM / ナビゲーション手術 / 医療者被ばく

Outline of Final Research Achievements

18F-FDG accumulation of resected specimens in breast-conserving surgery was evaluated with high resolution Positron Emission Mammography (PEM). In 16 cases, the invasive cancer lesion was detectable at 100% (12/12) and the noninvasive cancer lesion was detectable at 94.4% (17/18), and the medical staff exposure was as low as 18 μSV on average. The simulation was carried out when 2 cm margin was removed from the range of PEM accumulation, the amount of resection could be reduced by 58% without additional margin positive cases.
Furthermore, we have developed a highly sensitive thin and compact PEM using silicon photomultiplier, which makes it possible to detect 18 F-FDG in the operative field. It was able to separate 1.4 mm spaced pixels.

Free Research Field

乳癌