Mechanism analysis of estrogen addition therapy for metastatic breast cancer

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10057
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Kumamoto University
• Principal Investigator: Murakami Keiichi 熊本大学, 医学部附属病院, 非常勤診療医師 (20530124)
• Co-Investigator(Kenkyū-buntansha): 岩瀬 弘敬 熊本大学, 大学院生命科学研究部(医), 教授 (40211065)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 転移乳癌 / エストロゲン療法 / エストロゲン受容体 / ｃｆDNA

Outline of Final Research Achievements

Estrogen addition therapy may be effective for metastatic breast cancer that has become resistant to ordinary endocrine therapy. We collected metastatic lesions and blood specimens of patients treated with estrogen addition therapy over time, and examined the effect prediction and mechanism of the therapy.
The estrogen receptor (ER) after estrogen depletion therapy is highly expressed in metastatic lesion in many cases and it is difficult to show the effect afterwards in cases where ER gene mutation was found in cell free DNA in the blood It has been found.

Free Research Field

乳腺外科学