Ectopic expression of MECA-79 in breast cancer

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10058
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Fukushima Medical University
• Principal Investigator: Abe Noriko 福島県立医科大学, 医学部, 講師 (30622336)
• Co-Investigator(Kenkyū-buntansha): 岡山 洋和 福島県立医科大学, 医学部, 助教 (20583397) ; 大竹 徹 福島県立医科大学, 医学部, 教授 (50363750)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 乳癌 / 糖鎖

Outline of Final Research Achievements

We previously reported that a carbohydrate determinant, MECA-79, is ectopically expressed in gastric cancer, and is associated with clinical outcomes. The present study attempted to focus on the clinical and functional implication of MECA-79 expression in breast cancer, using breast cancer specimens and breast cancer cell lines, mainly by immunohistochemistry and flow cytometry. Unlike gastric and colorectal cancer, only approximately 5% of breast cancer was considered positive for MECA-79 expression, although MECA-79 expression was occasionally observed in membrane and/or cytoplasm of breast cancer cells. MECA-79 expression was not significantly associated with clinicopatholgical parameters or clinical outcomes in breast cancer. Flow cytometric analysis revealed that cell surface MECA-79 expression was found in none of the 5 breast cancer cell lines. The role of ectopic expression of MECA-79 in breast cancer remains unclear, and further studies would be required.

Free Research Field

乳腺外科