2017 Fiscal Year Final Research Report
| Project/Area Number |
15K10075
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Toin University of Yokohama |
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Principal Investigator |
OKUI Michiyo 桐蔭横浜大学, 先端医用工学センター, 講師 (20327654)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | PARP阻害剤 / microRNA |
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| Outline of Final Research Achievements |
Poly (ADP-ribose) polymerase inhibitors (PARPi) effectively kill homologous recombination deficient tumor cells through the concept of synthetic lethality. However, PARPi resistance frequently occurs, and therefore additional strategies that synergize with PARPi to enhance anti-tumor activity are necessary. To develop approaches for enhancing the effectiveness of PARPi, we demonstrated a microRNA array analysis to identify targets affected by treating medulloblastoma (MB) cells with the PARPi olaparib. We found that the expression level of miR-X, miR-Y, and miR-Z were selectively down-regulated in Brca2-deficient MB cells after olaparib treatment. These results suggest that miR-X, miR-Y, and miR-Z upregulation may improve the chemotherapeutic efficacy of olaparib in BRCA-proficient cancer.
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| Free Research Field |
分子生物学
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