Global genomic analysis of the stromal compartments of the esophagus toward the establishment of novel treatment for esophageal cancer.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10080
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Japanese Foundation for Cancer Research
• Principal Investigator: Ida Satoshi 公益財団法人がん研究会, 有明病院 消化器外科, 副医長 (80583038)
• Co-Investigator(Kenkyū-buntansha): 馬場 祥史 熊本大学, 医学部附属病院, 特任講師 (20599708) ; 今村 裕 公益財団法人がん研究会, 有明病院 消化器外科, 副医長 (70583045) ; 渡邊 雅之 公益財団法人がん研究会, 有明病院 消化器外科, 部長 (80254639)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 食道癌 / 間質 / エピゲノム

Outline of Final Research Achievements

In the esophageal cancer, various epigenetic alterations occur due to chronic inflammation accompanying with a history of smoking and alcohol drinking. We hypothesized that non-cancerous stroma might have epigenetic changes.
Genomic DNA was extracted from noncancerous stroma using tissue specimens of 42 resected esophageal cancer. Methylation level of long interspersed nuclear element (LINE - 1) was measured. The history of smoking exposure or alcohol drinking did not affect the LINE-1 hypomethylation. In addition, CIMP (CpG island methylator phenotype) positivity was not achieved in the eight types of cancer-related genes. These results suggested that epigenetic alterations were not observed in the non-cancerous stroma of the esophagus exposed by the smoking or drinking.

Free Research Field

消化器癌