2017 Fiscal Year Final Research Report
Functional analysis of TREX2 complex in the development and malignant progression of sporadic breast cancers
| Project/Area Number |
15K10083
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Niigata University (2016-2017)
Aichi Cancer Center Research Institute (2015) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 乳癌 / 転写共役型DNA傷害 |
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| Outline of Final Research Achievements |
We found that the deficiency of GANP, a member of TREX2 complex, resulted in the spontaneous development of mammary gland tumors in mice. To examine if GANP insufficiency is associated with human breast cancer development, we identified several SNPs of ganp and demonstrated one of the SNPs at the ganp locus was significantly associated with reduced breast cancer risk and longer disease-free survival in breast cancer patients. These results suggest that GANP is critical for the occurrence and progression of sporadic breast cancer. In addition, spliced variants in ganp mRNA lacking HAT enzymatic activity was observed in human breast cancer cases, suggesting that the development of sporadic breast cancers is involved in HAT activity of GANP.
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| Free Research Field |
腫瘍生物学、実験病理学
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