Establishment of the novel bio-marker for early detection and monitoring of gastric cancer with peritoneal dissemination

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10086
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Jichi Medical University (2016-2017); The University of Tokyo (2015)
• Principal Investigator: Yamaguchi Hironori 自治医科大学, 医学部, 教授 (20376445)
• Co-Investigator(Kenkyū-buntansha): 石原 聡一郎 東京大学, 医学部附属病院, 助教 (00376443) ; 北山 丈二 自治医科大学, 医学部, 教授 (20251308) ; 須並 英二 東京大学, 医学部附属病院, 登録研究員 (70345205) ; 渡邉 聡明 東京大学, 医学部附属病院, 助教授 (80210920) ; 石神 浩徳 東京大学, 医学部附属病院, 特任講師 (80372382)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 胃癌 / 腹膜播種 / 腹腔内化学療法 / バイオマーカー

Outline of Final Research Achievements

We quantitatively measured CEA mRNA in the 1268 samples of peritoneal lavage from 68 gastric cancer patients with peritoneal metastasis who received intraperitoneal chemotherapy. The MST of the 20 patients whose CEA mRNA index were below 100 in the preoperative samples was significantly higher compared with the 19 patients whose CEA mRNA index was over 100 (P<0.001). Multivariate analysis revealed that "CEA mRNA index over 100 in preoperative peritoneal lavage samples" was independent risk factor for over all survival in the patients who received gastrectomy after intraperitoneal chemotherapy. The value of CEA mRNA in peritoneal lavage samples is expected as a novel bio-marker for the prediction of the patient's prognosis who received intraperitoneal chemotherapy.

Free Research Field

胃癌 化学療法 手術療法