Establishment of postoperative adjuvant immunotherapy using peptide pool of tumor antigens in advanced esophageal cancer

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10100
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kobe University
• Principal Investigator: Nakamura Tetsu 神戸大学, 医学部附属病院, 講師 (10403247)
• Co-Investigator(Kenkyū-buntansha): 神垣 隆 神戸大学, 医学部附属病院, 講師 (20372641) ; 掛地 吉弘 神戸大学, 医学研究科, 教授 (80284488) ; 山下 公大 神戸大学, 医学部附属病院, 助教 (80535427)
• Co-Investigator(Renkei-kenkyūsha): AOI Takashi 神戸大学, 医学研究科, 特命教授 (00546997)
• Research Collaborator: TANAKA Tomoko 神戸大学, 医学部附属病院, 医員 ; NISHI Masayasu 神戸大学, 医学部附属病院, 医員
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 食道癌 / 補助療法 / T細胞 / ペプチドプール / 養子免疫

Outline of Final Research Achievements

In B16-OVA and EG-7 tumor-established mice, in which ovalbumin (OVA) was introduced into B16 melanoma cell line and EL4 T cell lymphoma, activation of antigen-specific T cells was confirmed. Since the number of antigen-specific T cells that can be harvested in the tumor was very small and it was difficult to detect, induction of antigen-specific T cells in the tumor was performed to improve the collection efficiency of intratumoral T cells. We will sequence these tumor reactive T cells and examine data consistency. After that, iPS cellularization will be carried out. We will establish this technology as soon as possible and try to apply human applications.

Free Research Field

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