Elucidation of the metastasis mechanism of cancer by the fibrinogen and application to new cancer treatment

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10113
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Nara Medical University
• Principal Investigator: Wakatsuki Kohei 奈良県立医科大学, 医学部, 学内講師 (10405384)
• Research Collaborator: MATSUMOTO Sohei ; ITO Masahiro ; MIGITA Kazuhiro ; NAKADE Hiroshi ; KUNISHIGE Tomohiro
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: フィブリノーゲン / 上部消化管がん / 予後因子

Outline of Final Research Achievements

For upper part gastrointestinal tract cancer (esophageal cancer, stomach cancer), we investigated the association between a plasma fibrinogen level and each clinicopathological factors and prognosis. As for the results, the plasma fibrinogen level (pFib) reflected a progress degree in stomach cancer and esophageal cancer. There was correlation between lymph node metastases and a venous invasion. There was association between pFib and lymphatic recurrence for esophageal cancer. The patients with high pFib significantly had a poorer prognosis than those with low pFib. pFib was an independent prognostic factor of stomach cancer and esophageal cancer. In upper part gastrointestinal tract cancer, we suggested that pFib reflected a cancer progression and was useful for predicting prognosis.

Free Research Field

消化器外科