2017 Fiscal Year Final Research Report
Development of new diagnosis and treatment procedures based on chemokine network for esophageal cancer
| Project/Area Number |
15K10116
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hamamatsu University School of Medicine (2016-2017)
Keio University (2015) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 食道扁平上皮癌 / ケモカイン / CXCL12 / IL-8 / CCL5 |
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| Outline of Final Research Achievements |
Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers worldwide. The purpose of this study was to develop a new method for evaluating the degree of malignancy of ESCC and a novel therapeutic approach for ESCC focusing on chemokine network. Immunohistochemical analysis of the past surgical specimen revealed that positive expression of CXCL12-CXCR4, IL8-CXCR2, and CCL5-CCR5 were the independent prognostic factors as well as histological stage, and the number of expressing networks had correlation with poor prognosis. Secondly, we reported that the proliferative ability of ESCC overexpressing or exposed to above mentioned chemokine were significantly enhanced compared with wildtype cells in vitro. Third, the antagonists of chemokine receptors inhibited the tumor growth of ESCC in vivo. Taken together, chemokine network was not only a promising biomarker but also a novel molecular target for inhibiting ESCC proliferation.
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| Free Research Field |
消化器外科学
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