Mechanisms of liver metastasis via alteration of miRNA expression in gastrointinal malignancies

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10132
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Kikuchi Hirotoshi 浜松医科大学, 医学部附属病院, 講師 (70397389)
• Co-Investigator(Kenkyū-buntansha): 今野 弘之 浜松医科大学, 医学部, 学長 (00138033)
• Research Collaborator: Murakami Tomohiro 浜松医科大学, 大学院生 ; Ishimatsu Hisato 浜松医科大学, 大学院生 ; Baba Satoshi 浜松医科大学, 医学部附属病院, 病院教授 ; Kitagawa Masatoshi 浜松医科大学, 医学部, 教授 ; Kitagawa Kyoko 浜松医科大学, 医学部, 助教
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: マイクロRNA / 肝転移 / 腫瘍間質 / 微小環境 / tenascin C

Outline of Final Research Achievements

To identify mechanisms of liver metastasis, microRNA expression was analyzed in colorectal cancer (CRC) stroma and gastrointestinal stromal tumors (GISTs). In CRC,
suppression of miR-198 in tumor stroma appears to form a metastasis-permissive environment that can elevate tenascin C to promote liver metastasis. Tenascin C expression in CRC stroma was identified as a novel molecular marker of CRC to predict postoperative liver metastasis. In GIST, overexpression of miR-122 and concomitant suppression of CAT1, and suppression of miR-133b and concomitant overexpression of fascin-1 protein appear to play important roles in the development of liver metastasis.

Free Research Field

消化器外科学