Development of cancer predictive diagnosis and therapy using new biomarker of colorectal cancer

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10150
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Teikyo University
• Principal Investigator: Iinums Hisae 帝京大学, 医学部, 講師 (30147102)
• Co-Investigator(Kenkyū-buntansha): 橋口 陽二郎 帝京大学, 医学部, 教授 (60251253)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: Colon cancer / Liquid biopsy / CTC / microRNA / exosome / cell- free DNA / Biomarker

Outline of Final Research Achievements

In a liquid biopsy of colorectal cancer　patients, the usefulness as a biomarker of circulating tumor cells (CTC), plasma exosome-encapsulating microRNA, plasma cell free DNA was examined. CTC, microRNA and cell-free DNA were useful as cancer recurrence and prognostic markers. Analysis of CTC with the next generation sequence revealed a new genetic mutation in CTC of the recurrent case. microRNA-21 (miR-21) and miR-X were excellent markers for early diagnosis of colorectal cancer. The gene mutation of cell free DNA was correlated with the results of RECIST, and it was confirmed that cell free DNA was able to predict treatment effect earlier than CT.

Free Research Field

分子腫瘍学