2017 Fiscal Year Final Research Report
Role of M-CSF in hepatocarcinogenesis
| Project/Area Number |
15K10159
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
河野 寛 山梨大学, 大学院総合研究部, 准教授 (40322127)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | マクロファージ / M-CSF / 肝細胞癌 |
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| Outline of Final Research Achievements |
Aim：The purpose of this study was to investigate effects of M-CSF receptor antagonist on HCC. Materials and Method：C57/BL6 mice were treated with diethyl nitrosamine (DEN) intraperitoneally. For treatment group, M-CSF receptor antagonist (GW2580) was treated every day. Incidence of tumors was assessed after treatment. Mouse HCC cells (MH134) were implanted to same strain C3H mice by subcutaneous injection (1 ×105/animal). Tumor progression was assessed after 3 weeks.In the nude mouse, human HCC cells (HuH7) were implanted by intra-splenic injection. Tumor progression in the spleen was assessed after 3 weeks.Result：Hepatic tumors diagnosed as hepatocellular adenoma or HCC were observed in animals treated with DEN. In contrast, tumor incidence was significantly reduced in DEN-treated animals with GW2580. Growth of implanted both of HCC was significantly inhibited by GW2580 in vivo. Conclusions：M-CSF and/or its receptor could be a new therapeutic target for HCC.
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| Free Research Field |
消化器外科学
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