Development of novel therapeutic agent targeting pancreatic cancer stroma by screening compound library

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10188
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kyushu University
• Principal Investigator: TOMINAGA Yohei 九州大学, 医学研究院, 共同研究員 (90304823)
• Co-Investigator(Kenkyū-buntansha): 森山 大樹 九州大学, 大学病院, 准教授 (70586859) ; 水元 一博 九州大学, 大学病院, 准教授 (90253418) ; 大内田 研宙 九州大学, 大学病院, 講師 (20452708)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 化合物ライブラリー / 癌間質相互作用 / 間質標的治療 / 膵星細胞 / 化合物スクリーニング

Outline of Final Research Achievements

In the present study, we demonstrated that cancer-associated stroma would become a new target for the treatment of pancreatic cancer. We focused on pancreatic stellate cells(PSCs) as a therapeutic target and developed a novel screening assay system to detect the activation of PSCs. Then we performed high-throughput screening using this assay, and we showed 152 compounds led PSCs into quiescent state. These data suggest that the drugs targeting PSCs may become a novel strategy for pancreatic cancer therapy.

Free Research Field

医歯薬学