Lanthanum carbonate inhibits aortic allograft calcification in circulatory transplant models

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10207
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: The University of Tokyo
• Principal Investigator: Yamauchi Haruo 東京大学, 医学部附属病院, 講師 (60726735)
• Co-Investigator(Kenkyū-buntansha): 小野 稔 東京大学, 医学部附属病院, 教授 (40270871) ; 木下 修 東京大学, 医学部附属病院, 特任講師 (40598512) ; 益澤 明広 東京大学, 医学部附属病院, 特任講師 (30709572)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 同種心臓弁・血管移植 / 石灰化 / リン酸バインダー

Outline of Final Research Achievements

<OBJECTIVES> Limited durability of a cardiovascular homograft due to accelerated calcification in young recipients is an unsolved problem. We hypothesized that phosphate binder, lanthanum carbonate (LC) inhibits calcification of a transplanted homograft, and examine this hypothesis by circulatory transplant rabbit model. <METHODS> Donor aortas were transplanted to carotid arteries of recipients. All the recipients were euthanized after 8 weeks and the homograft were explanted. LC group rabbits were fed by a diet containing LC for 1, 2, 4, 8 weeks postoperatively followed by feeding normal diets. The results were compared with those from control group rabbits which were fed by a normal diet. <RESULTS> Homograft calcification was inhibited in the LC group by giving LC for at least 2 weeks, but growth retardation was seen in the rabbits with LC for 8 weeks. <CONCLUSIONS> Short-term LC may safely inhibit aortic homograft calcification without significant side effects.

Free Research Field

医師薬学