Investigation for the attenuation of arrhythmia related to human iPS cell-based cardiac regenerative therapy

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10209
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Kyoto University
• Principal Investigator: Sakaguchi Hisashi 京都大学, 医学研究科, 客員研究員 (40743026)
• Co-Investigator(Kenkyū-buntansha): 池田 義 京都大学, 医学研究科, 准教授 (40281092) ; 南方 謙二 京都大学, 医学研究科, 講師 (60539675) ; 杉山 篤 東邦大学, 医学部, 教授 (60242632)
• Co-Investigator(Renkei-kenkyūsha): YAMASHITA JUN 京都大学, その他部局等, 教授 (50335288)
• Research Collaborator: MASUMOTO HIDETOSHI 京都大学, 大学院医学研究科, 特定助教 (70645754)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: iPS細胞 / 心筋梗塞 / 重症心不全 / 致死性不整脈 / ホルター心電図 / マイクロミニピッグ

Outline of Final Research Achievements

The Holter ECG after human iPS cell-derived cardiac tissue transplantation showed no occurrence of lethal arrhythmia whereas there was the occurrence of ventricular tachycardia in sham group pigs after induction of myocardial infarction. The variability of QT interval is known to be a marker of arrhythmia and was lower in cell sheet transplantation group compared to that in sham group. Here we showed the safety of human iPS cell-based cardiac regenerative therapy using pigs with similar heart rate with human. We also showed the occurrence of Torsade de Pointes which is known to be a lethal arrhythmia after administration of already known cardiotoxic drugs. Here we showed a basis of the occurrence of arrhythmia related to human iPS cell-based cardiac regenerative therapy.

Free Research Field

心臓血管外科学