• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2017 Fiscal Year Final Research Report

Gene and Cell Therapy for Lymphedema

Research Project

  • PDF
Project/Area Number 15K10229
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular surgery
Research InstitutionAsahikawa Medical College

Principal Investigator

SAITO Yukihiro  旭川医科大学, 医学部, 講師 (80540583)

Project Period (FY) 2015-04-01 – 2018-03-31
Keywordsリンパ管内皮細胞 / iPS細胞
Outline of Final Research Achievements

The purpose of this study is to induce iPS cells into lymphatic endothelial cells by transfection of hepatocyte growth factor (HGF) plasmid DNA. 1) We could not obtain the mouse iPS cell line of HGF stable expression. 2) We could not establish the lymphatic endothelial cell line from mouse iPS by co-culture method with OP-9. 3) When HGF was expressed in iPS cell transiently, lymphatic cell markers, such as Sox18, FoxC2, VEGFR3, and Prox1, were up-regulated at 5-day after transfection, but these up-regulation were neutralized at 14-day.

Free Research Field

血管外科

URL: 

Published: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi