Novel cell-based therapeutic strategies focusing on vessel maturation for severe peripheral vascular diseases

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10244
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Yamaguchi University
• Principal Investigator: HOSOYAMA Tohru 山口大学, 大学院医学系研究科, 助教 (20638803)
• Co-Investigator(Kenkyū-buntansha): 濱野 公一 山口大学, 大学院医学系研究科, 教授 (60263787) ; 森景 則保 山口大学, 医学部附属病院, 講師 (50335741)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 細胞移植治療 / 下肢虚血 / 低酸素プレコンディショニング / アペリン

Outline of Final Research Achievements

Although cell-based therapy for severe peripheral vascular diseases is promising, it is needed to be improved to obtain higher therapeutic outcomes for clinical application. In this study, we investigated if combination therapy of cell-based therapeutic angiogenesis with vessel maturing drug was useful for severe hindlimb ischemia, and we also investigated to clarify the mechanism of its action. As a result, this hybrid therapeutic strategy resulted in effective maturation of new vessels by cell-based therapy. This strategy will be expected to become novel and low invasive therapeutic approach for severe hindlimb ischemia.

Free Research Field

心臓・血管外科