Potential novel treatment for aortic aneurysm with hydorogen sulfide

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10250
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Kurume University
• Principal Investigator: Otsuka Hiroyuki 久留米大学, 医学部, 助教 (30441645)
• Co-Investigator(Kenkyū-buntansha): 青木 浩樹 久留米大学, 付置研究所, 教授 (60322244) ; 明石 英俊 久留米大学, 医学部, 教授 (80184084) ; 田中 啓之 久留米大学, 医学部, 教授 (70197466)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 大動脈瘤 / 硫化水素

Outline of Final Research Achievements

Aortic aneurysm is a common and fatal disease, of which molecular　mechanism involves chronic inflammation and tissue destruction. On the other hands, Hydrogen sulfide (H2S) has been recognized as a gasotransmitter molecule with a variety of physiological functions on circulation. In this project, H2S is not affect the formation of human abdominal aortic aneurysm, and Diallyl trisulfide (DATS), a stable H2S donor has not been shown to significantly inhibit the expression of IL-6 and MMP-9 on the abdominal aortic aneurysm. However, It was suggested that DATS might have the effect of promoting the production of MMP-9 on the human abdominal aortic aneurysm.

Free Research Field

大動脈疾患