Elucidation of the role of TLRs and its downstream factors in lung cancer progression

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10266
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory surgery
• Research Institution: Kagoshima University
• Principal Investigator: Aoki Masaya 鹿児島大学, 医歯学域医学系, 助教 (50624996)
• Co-Investigator(Kenkyū-buntansha): 狩集 弘太 鹿児島大学, 医歯学域附属病院, 助教 (20648050) ; 佐藤 雅美 鹿児島大学, 医歯学域医学系, 教授 (30250830) ; 大塚 綱志 鹿児島大学, 医学部・歯学部附属病院, 助教 (40464466) ; 中村 好宏 鹿児島大学, 医歯学域附属病院, 講師 (60381159) ; 永田 俊行 鹿児島大学, 附属病院, 医員 (70611763)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: TLR4 / MyD88 / 非小細胞肺癌 / 免疫染色 / 細胞実験

Outline of Final Research Achievements

We examined immunohistological expression of TLR4 and MyD88 in resected specimens of nonsmall cell lung cancer and evaluated correlation with clinicopathological factors and prognosis. Although the results are unpublished, it is clear that the expression of TLR4 and MyD88 in lung cancer correlates with clinicopathological factors and prognosis. At the present, it is preparatory stage for research in vitro and in vivo, and we plan to demonstrate it in more fundamental research. Lung cancer cell lines used for in vitro and in vivo studies have already been purchased, it is a situation where cells can be proliferated and passaged and can be transferred to research at any time.

Free Research Field

呼吸器外科