2017 Fiscal Year Final Research Report
Combined therapy for brain infarction with slow releasing drug delivery system and immature cells.
| Project/Area Number |
15K10291
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 脳梗塞 / 幹細胞治療 / Drug delivery system |
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| Outline of Final Research Achievements |
1)Brain infarction rats were treated using adipose-cell derived stem cells (ACSC), which were injected intra-arterially. Results: The mortality of ACSC-treated rats was lower than that of control rats. In survived brain infarction rats, infarction area of ASCS-treated rats was significantly decreased than that of control rats. Neurological examination was also improved in ASCS-treated rats. Hitological examination showed the existence of ACSC in brain infarction area.
2)Drug delivery system slowly releasing cytokines to central nervous system was developed. Cytokines were loaded on burr hole button that was used in cranioplasty as bone filling biomaterials. In-vivo slow releasing of cytokines was recognized from this burr hole button.
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| Free Research Field |
脳神経外科
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