Cerebral blood flow measurement by arterial spin labeling MRI in pregnant women

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10294
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: TANAKA Yoji 東京医科歯科大学, 医学部附属病院, 講師 (80323682)
• Co-Investigator(Kenkyū-buntansha): 成相 直 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (00228090) ; 宮坂 尚幸 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (70313252)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 脳血流 / 正常妊娠 / もやもや病合併妊娠 / MRI / arterial spin labeling

Outline of Final Research Achievements

[PURPOSE] To evaluate the maternal cerebral blood flow (CBF) change measured by arterial spin labeling (ASL) MRI in healthy subjects and in the patients with cerebrovascular disease (CVD). [SUBJECTS AND METHODS] ASL was performed to the healthy non-pregnant women (Group A, n=10), healthy pregnant women (Group B, n=8), and pregnant women with CVD, including 28 cases of moyamoya disease (MMD). 16 of MMD patients also had ASL-MRI at non-pregnant period. [RESULTS] In healthy groups, global CBF showed no significant change during pregnant period. Regional distribution of CBF was also similar between group A and B. Contrarily, the global CBF significantly dropped during pregnancy in the MMD patients. Among the MMD patients, 7 had multiple scans in different trimester of pregnancy and suggested that CBF dropped in the 3rd trimester. [CONCLUSIONS] The result indicated that cerebral hemodynamic may change differently between healthy women and the patients with MMD.

Free Research Field

脳神経外科学