Elucidation of the role of Wnt in tumor immunity of malignant glioma and its application to therapy

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10338
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Kagoshima University
• Principal Investigator: HIRANO Hirofumi 鹿児島大学, 医歯学域医学系, 准教授 (00264416)
• Co-Investigator(Kenkyū-buntansha): 岸田 昭世 鹿児島大学, 医歯学域医学系, 教授 (50274064) ; 米澤 大 鹿児島大学, 医学部・歯学部附属病院, その他 (50550076) ; 内田 裕之 鹿児島大学, 医学部・歯学部附属病院, その他 (80404482) ; 有田 和徳 鹿児島大学, 医歯学総合研究科, 客員研究員 (90212646)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: Wnt-5a / グリオーマ / 相互作用 / 免疫 / PD-L1 / 膠芽腫

Outline of Final Research Achievements

We studied the relationship between intratumoral expression of Wnt and expression of PDL-1 and therapeutic effect, but the correlation between Wnt5a and PD-L1 expression in glioblastoma was weak, and the expression level of PD-L1 in patients with glioblastoma did not show the difference in survival time.
In the analysis of Gene Expression Omnibus Database, there was PD-1 as a highly correlated gene candidate with Wnt-5a, but in vitro study the gene expression change related to immunosuppression of tumor cells by Wnt5a stimulation could not detected, and macrophage-mediated influence was no obvious in expression of immunity checkpoint-related genes.

Free Research Field

脳神経外科学分野