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2016 Fiscal Year Research-status Report

グリオーマ癌幹細胞を標的とした樹状細胞療法の開発に関する基礎研究

Research Project

Project/Area Number 15K10346
Research InstitutionKansai Medical University

Principal Investigator

淺井 昭雄  関西医科大学, 医学部, 教授 (50231858)

Co-Investigator(Kenkyū-buntansha) 岩田 亮一  関西医科大学, 医学部, 助教 (60580446)
伊藤 量基  関西医科大学, 医学部, 准教授 (70434826)
Project Period (FY) 2015-04-01 – 2018-03-31
Keywordsグリオーマ / 樹状細胞 / 癌幹細胞 / 免疫治療
Outline of Annual Research Achievements

免疫が正常なマウス脳腫瘍モデルを作成するために、マウス神経幹細胞にがん遺伝子を導入したグリオーマがん幹細胞株(RasR)を入手した。
RasRは、HLA class1が発現していることをフローサイトメトリーで確認した。つまり、T細胞に認識されるため、樹状細胞治療が可能であることが判明した。
RasRをBL6マウスに移植することで、免疫能が正常であるマウス脳腫瘍モデルを作成した。移植後約30日で腫瘍死することを確認した。

Current Status of Research Progress
Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

免疫正常マウス脳腫瘍モデルは作成できた。マウスから樹状細胞の単離ができていない。

Strategy for Future Research Activity

まずは、tumor lysateによるがんワクチンで誘導される免疫応答について解析を行う。

Causes of Carryover

購入品の納品日が遅延した為

Expenditure Plan for Carryover Budget

マウス購入費、遺伝子解析のためのPCR関連試薬

  • Research Products

    (10 results)

All 2017 2016

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 3 results) Presentation (3 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Journal Article] Application of transpulmonary thermodilution monitoring (PiCCO) in patients with neurogenic pulmonary edema and acute obstructive hydrocephalus due to a central neurocytoma: A case report.2017

    • Author(s)
      R Iwata, K Yoshimura, Y Fujita, T Uesaka, H Oshige, A Asai
    • Journal Title

      Interdisciplinary Neurosurgery: Advanced Techniques and Case Management

      Volume: 8 Pages: 57-59

    • DOI

      http://doi.org/10.1016/j.inat.2017.01.014

    • Peer Reviewed / Open Access
  • [Journal Article] Hyperperfusion syndrome after clipping of an unruptured aneurysm by transsylvian approach: A Case Repot.2017

    • Author(s)
      R Iwata, K Yoshimura, Y Fujita, T Uesaka, H Oshige, A Asai
    • Journal Title

      Interdisciplinary Neurosurgery: Advanced Techniques and Case Management.

      Volume: 8 Pages: 11-13

    • DOI

      http://doi.org/10.1016/j.inat.2017.01.010

    • Peer Reviewed / Open Access
  • [Journal Article] Genome-wide methylation profiles in primary intracranial germ cell tumors indicate a primordial germ cell origin for germinomas.2017

    • Author(s)
      Fukushima S, Yamashita SNonaka M, Asai A, Kawahara N, Hirose Y, Takayama T, Nakazato Y, Narita Y, Shibata T, Matsutani M, Ushijima T, Nishikawa R, Ichimura K
    • Journal Title

      Acta Neuropathol.

      Volume: 133(3) Pages: 445-462

    • DOI

      10.1007/s00401-017-1673-2.

    • Peer Reviewed
  • [Journal Article] Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-dependent Manner.2016

    • Author(s)
      Kim SH, Ezhilarasan R, Phillips E, Gallego-Perez D, Sparks A, Taylor D, Ladner K, Furuta T, Sabit H, Chhipa R, Cho JH, Mohyeldin A, Beck S, Kurozumi K, Kuroiwa T, Iwata R, Asai A, Kim J, Sulman EP, Cheng SY, Lee LJ, Nakada M, Guttridge D, DasGupta B, Goidts V, Bhat KP, Nakano I.
    • Journal Title

      Cancer Cell.

      Volume: 29 Pages: 201-13

    • DOI

      10.1016/j.ccell.2016.01.005

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Recurrent neomorphic mutations of MTOR in central nervous system and testicular germ cell tumors may be targeted for therapy.2016

    • Author(s)
      Ichimura K, Fukushima S,Nonaka M, Asai A, Yokogami K, Takeshima H, Kawahara N, Takayama T, Yao M, Kato M, Nakamura H, Hama N, Sakai R, Ushijima T, Matsutani M, Shibata T, Nishikawa R
    • Journal Title

      Acta Neuropathol.

      Volume: 131(6) Pages: 889-901

    • DOI

      10.1007/s00401-016-1557-x

    • Peer Reviewed
  • [Journal Article] 治療後長期間生存している悪性視神経膠腫の1 例.2016

    • Author(s)
      藤原望, 中内正志, 正健一郎, 山田晴彦, 最所千晶, 岩田亮一, 亀井孝昌, 淺井昭雄, 髙橋寛二
    • Journal Title

      臨床眼科

      Volume: 70 Pages: 1473-1478

    • Peer Reviewed
  • [Presentation] 内視鏡下5アミノレブリン酸(5-ALA)蛍光診断(PDD)~連続45症例の検討~.2016

    • Author(s)
      武田純一, 埜中正博, 亀井孝昌, 岩田亮一, 羽柴哲夫, 吉村晋一, 淺井昭雄.
    • Organizer
      第34回日本脳腫瘍学会学術集会.
    • Place of Presentation
      甲府富士屋ホテル、山梨
    • Year and Date
      2016-12-04 – 2016-12-06
  • [Presentation] Effect of Temozolomide on Brain Metastasis of neuroendocrine carcinoma.2016

    • Author(s)
      Ryoichi Iwata, Masato Maruyama, Tomoki Ito, Yoko Fujita, Yoshiyuki Matsuo, Yosuke Nakano, Kunikazu Yoshimura, Masahiro Nonaka, Kiichi Hirota, Shosaku Nomura, Tetsuo Sugimoto, Akio Asai.
    • Organizer
      The 13th Asian Society for Neuro-oncology (ASNO) Meeting.
    • Place of Presentation
      Sheraton on the Park, Sydney, Australia
    • Year and Date
      2016-09-11 – 2016-09-14
    • Int'l Joint Research
  • [Presentation] Therapeutical Doses of Temozolomide Inhibit IL-10 Production by Dendritic Cells and Enhance the CTL Response.2016

    • Author(s)
      Akio Asai, Ryoichi Iwata, Tomoki Ito, Muneo Inaba, Noriko Katashiba, Kayoko Kibata, Akihiro Tanaka, Shosaku Nomura.
    • Organizer
      The 21st International Conference on Brain Tumor Research and Therapy.
    • Place of Presentation
      Bankoku Shinryokan, Okinawa
    • Year and Date
      2016-04-10 – 2016-04-13
  • [Book] 【脳腫瘍学-基礎研究と臨床研究の進歩-】 転移性脳腫瘍 転移性脳腫瘍の治療2016

    • Author(s)
      岩田亮一、淺井昭雄
    • Total Pages
      5
    • Publisher
      日本臨牀

URL: 

Published: 2018-01-16  

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