Development of imaging method and novel clinical application for intraoperative diagnostic in microneurosurgery using photoacoustic imaging technology

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10379
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: National Defense Medical College
• Principal Investigator: OTANI NAOKI 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 病院 脳神経外科, 講師 (20573637)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 顕微鏡下手術 / 光音響画像

Outline of Final Research Achievements

In brain microsurgery, it is important to confirm the prompt, accurate and reproducible positional relationship between the lesion and surrounding cerebral vessels intraoperatively. We herein focus on intraoperative application of photoacoustic imaging technology, which spotlighted as a new image diagnostic tool. This method enabling imaging of a fine vascular network without using a contrast medium but there was no application to brain surgery operation. We have performed successful non-invasive visualization of subcutaneous blood vessels, cerebral vascular vessels of brain tumor vessels. We also confirmed the abnormal brain lesion and the visualization of the surrounding cerebral vessels. In addition, we enable to evaluate the machine characteristics such as spatial resolution, sensitivity, operability and reproducibility during the operative procedure. These data revealed its usefulness in micro-neurosurgery.

Free Research Field

脳神経外科