Pathological of neuropathic pain with chronic progressive spinal cord compression.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10391
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: University of Fukui
• Principal Investigator: Takeura Naoto 福井大学, 学術研究院医学系部門, 特別研究員 (00615304)
• Co-Investigator(Kenkyū-buntansha): 中嶋 秀明 福井大学, 学術研究院医学系部門, 講師 (10397276) ; 内田 研造 福井大学, 医学部, 教授 (60273009)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 脊髄慢性圧迫 / twyマウス / MAPK / マクロファージ

Outline of Final Research Achievements

To identify the cell type that expressed p-p38 and p-ERK MAPK in spinal cord with chronic compression. Of 12 weeks old twy/twy mice, double stained cells for p-ERK and CD11b were rarely found. The cell markers showed that p-p38 MAPK-IR cells completely co-localized with CD11b, but not with either GFAP or NeuN at all-time points examined. The rate of MAPK-positive/ GFP-positive cells was higher as the degree of the compression of spinal cord. As a result of this research, we suggested that in the spinal cord with chronic compression the failure and hyperpermeability of BSCB could be occur according to compression degree and that hematogenous macrophage would be random migration in the spinal cord could be as one of the clinical condition of the neuropathic pain.

Free Research Field

脊髄　基礎研究