2017 Fiscal Year Final Research Report
Development of a novel treatment for neuropathic pain by regulating mitochondrial function in Schwann cells
Project/Area Number |
15K10405
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Osaka University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
岡田 潔 大阪大学, 医学(系)研究科(研究院), 助教 (40576279)
岡 久仁洋 大阪大学, キャンパスライフ健康支援センター, 助教 (50724085)
村瀬 剛 大阪大学, 医学系研究科, 准教授 (50335361)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Keywords | シュワン細胞 / ミトコンドリア / 神経因性疼痛 |
Outline of Final Research Achievements |
We found that methylcobalamin, which is used as a therapeutic agent for peripheral neuropathy, is one of candidate substances to regulate mitochondrial function in Schwann cells. Methylcobalamin increases the NAD+/NADH value, which is an indicator of mitochondrial function in Schwann cells, inhibits dedifferentiation and promotes differentiation/myelination of Schwann cells in vitro. Methylcobalamin also inhibits demyelination of peripheral nerve in vivo. It was suggested that methylcobalamin could be a novel treatment for neuropathic pain by regulating the mitochondrial function in Schwann cells.
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Free Research Field |
整形外科学
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