Identification and functional analysis of candidate causal genes of the ossification of posterior longitudinal ligament of the spine

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10410
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Kagoshima University
• Principal Investigator: Kawamura Ichiro 鹿児島大学, 医歯学総合研究科, 客員准教授 (90535832)
• Co-Investigator(Kenkyū-buntansha): 前田 真吾 鹿児島大学, 医歯学総合研究科, 特任准教授 (60353463) ; 小宮 節郎 鹿児島大学, 医歯学域医学系, 教授 (30178371)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 後縦靭帯骨化症 / GWAS

Outline of Final Research Achievements

We tried to isolate mRNA from posterior longitudinal ligament of cervical spine of mice, however, we could not because the tissue was too small. We selected candidate causal genes of OPLL in the sensitive genome area identified by GWAS, and performed immunohistochemistry against the coding proteins. All the selected proteins were detected in the degenerated ligament cells in the OPLL specimens.

Free Research Field

整形外科学、脊椎外科学