New treatment for Dupuytren disease by sex hormone control

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10416
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Osaka City University
• Principal Investigator: IEGUCHI Makoto 大阪市立大学, 大学院医学研究科, 登録医 (70275246)
• Co-Investigator(Kenkyū-buntansha): 上村 卓也 大阪市立大学, 大学院医学研究科, 病院講師 (10597321) ; 岡田 充弘 大阪市立大学, 大学院医学研究科, 講師 (40309571)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: デュプイトラン拘縮 / アンドロゲン / 示指長/環指長比

Outline of Final Research Achievements

On the relationship between Dupuytren disease and androgen, the index finger length / ring finger length ratio was measured, and the Dupuytren disease patients had significantly lower index / length ratio than the non-Dupuytren disease patients. In addition, it was confirmed histologically that myofibroblasts are concentrated in the pathological aponeurosis at the finger. The relationship between Dupuytren disease and androgen was confirmed from the X-ray image. The localization of myofibroblasts with androgen receptor is involved in poor performance of surgery. From this research, the local administration of androgen inhibitors to the focal site of myofibroblasts among pathologic aponeurosis can be a future therapeutic strategies.

Free Research Field

骨軟部腫瘍