An establishment of risk prediction of skeletal-related event in patients with bone metastatic cancer by evaluating bone strength

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10423
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Aichi Medical University
• Principal Investigator: Wakao Norimitsu 愛知医科大学, 医学部, 講師 (80528802)
• Co-Investigator(Kenkyū-buntansha): 中野 正吾 愛知医科大学, 医学部, 教授 (20351108) ; 住友 誠 愛知医科大学, 医学部, 教授 (50255535) ; 三嶋 秀行 愛知医科大学, 医学部, 教授 (70520881)
• Co-Investigator(Renkei-kenkyūsha): SUMITOMO Makoto 愛知医科大学, 泌尿器科学, 教授 (50255535)
• Research Collaborator: MISHIMA Hideyuki 愛知医科大学, 臨床腫瘍センター, 教授 (70520881)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 癌骨転移 / 骨強度 / 有害事象 / リスク / デノスマブ

Outline of Final Research Achievements

Overall 24 cases with bone metastasis was enrolled in this case series study (Lung cancer: 8 cases, Prostate cancer: 6 cases, Breast cancer: 5 cases, Colon cancer: 3 cases, Pancreas cancer: 1 case, and thyroid cancer: 1 case). 2 cases with lung cancer, 1 case with pancreas cancer, and 1 case with colon cancer have died because of cancer itself during the following up period. Fortunately, none of them has been suffered from a skeletal-related adverse event, and pain related to the bone metastasis and performance status have been well controlled.
However, the capability of bone restoration drugs for avoiding spinal paralysis could not be calculated because there were no patients with spinal paralysis associated with bone metastasis from the results of our case series study, the effect of pain relief of bone restoration drugs were significantly remarkable in patients with bone metastasis originated from lung cancer and bone, which showed osteolytic changes in computed tomography images.

Free Research Field

脊椎脊髄外科