2017 Fiscal Year Final Research Report
Analysis of mechanism of healing acceleration in soft tissue injuries under hyperbaric oxygen condition.
| Project/Area Number |
15K10433
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
加藤 剛 東京医科歯科大学, 医学部附属病院, 助教 (80447490)
榎本 光裕 東京医科歯科大学, 医学部附属病院, 非常勤講師 (90451971)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 高気圧酸素 / 骨格筋 / 圧挫損傷 / 血管透過性 / 筋再生 / 筋衛星細胞 |
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| Outline of Final Research Achievements |
We assessed the effects of hyperbaric oxygen treatment (HBO) on contused calf muscles in a rat skeletal muscle injury model. An experimental HBO chamber was developed and rats were treated with 100% oxygen, 2.5 atmospheres absolute for 2h/day after injury. HBO reduced early lower limb volume and muscle wet weight in contused muscles, and promoted muscle isometric strength 7 days after injury. HBO suppressed the elevation of circulating macrophages in the acute phase and then accelerated macrophage invasion into the contused muscle. This environment also increased the number of proliferating and differentiating satellite cells and the amount of regenerated muscle fibers. Our results demonstrate that HBO has a dual role in decreasing inflammation and accelerating myogenesis in muscle contusion injuries.
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| Free Research Field |
高気圧酸素医学
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