2017 Fiscal Year Final Research Report
Development of new therapy for malignant bone and soft tissue tumor by targeting bone marrow stromal cells
| Project/Area Number |
15K10449
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 骨軟部腫瘍 / 骨髄間質細胞 |
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| Outline of Final Research Achievements |
The clinical prognosis of localized malignant bone and soft tissue tumors are improved by systemic chemotherapy. However, the prognosis of the advanced cases of those tumors remains dismal. In this study, we investigated the roles of bone marrow stem cells (BMSC), as well as tumor cells, in the tumor biology of malignant bone and soft tissue tumors. We found that, in Ewing's sarcoma, cadherin-11 on BMSC regulated the bone metastasis of Ewing's sarcoma cells. We also proved that, in synovial sarcoma, the activation of Erk pathway was critical for the drug resistance for pazopanib, a multi-kinase inhibitor.
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| Free Research Field |
整形外科
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