2017 Fiscal Year Final Research Report
Regulation of articular joint diseases by transcription factor family C/EBP
| Project/Area Number |
15K10462
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
田中 健之 東京大学, 医学部附属病院, 助教 (00583121)
矢野 文子 東京大学, 医学部附属病院, 特任講師 (80529040)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 整形外科学 / 変形性関節症 |
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| Outline of Final Research Achievements |
CCAAT/enhancer-binding protein (C/EBP) beta regulates chondrocyte differentiaion and proliferation during endochondral ossification. In the present study, we examined expression and function of other C/EBP family members in chondrocytes. Among
four members with transactivation domain, expression of Cebpb and Cebpd was abundant compared to Cebpa. C/EBPs suppressed expressions of early differentiation
markers including Col2a1, aggrecan and Sox9, enhanced those of late differentiation markers including Mmp13, Vegfa and Col10a1, and decelerated cell proliferation, indicating their overlapped functions in chondrocytes. In contrast, A-CEBP, which exerts a dominant-negative effect against all C/EBPs, increased expressions of early differentiation markers and decreased those of late differentiation markers.
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| Free Research Field |
整形外科学
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