Mechanism of glutathione-induced stimulation of osteoclast differentiation

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10475
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Okayama University
• Principal Investigator: Fujita Hirofumi 岡山大学, 医歯薬学総合研究科, 助教 (20423288)
• Co-Investigator(Kenkyū-buntansha): 小渕 浩嗣 岡山大学, 医歯薬学総合研究科, 講師 (10304297)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: osteoclast / glutathione / inflammation / differentiation

Outline of Final Research Achievements

Previously, we reported that glutathione have a role in molecular mechanism of osteoclast differentiation. To clarify mechanisms of the stimulatory effect of glutathione on osteoclast differentiation, we tried to establish knockout mice of glutathione-related molecules which are expressed specifically in osteoclasts. Using CRISPR-Cas9 system, we were able to establish a knockout mice strain of glutathione-related molecules.

Free Research Field

骨代謝学、レドックス制御