2017 Fiscal Year Final Research Report
Analysis for pathogenesis of shoulder degenerative disease
| Project/Area Number |
15K10484
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中島 利博 東京医科大学, 医学部, 教授 (90260752)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 肩腱板断裂 / 筋内脂肪変性 |
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| Outline of Final Research Achievements |
Although various surgical procedures have been developed, the re-tear rate after rotator cuff repair remains high with severe fat infiltration. In this study, we addressed the role of high-mobility group box 2 (HMGB2) in adipogenesis of mesenchymal stem cells (MSCs) and fat infiltration into skeletal muscles. HMGB2 was highly expressed in undifferentiated MSCs and co-localized with platelet-derived growth factor receptor α (PDGFRA) known as an MSC-specific marker. Under the deficiency of HMGB2, the expressions of adipogenesis-related molecules were reduced, and adipogenic differentiation is substantially impaired in MSCs. Moreover, HMGB2+ cells were generated in the muscle belly of rat supraspinatus muscles after rotator cuff transection, and some of these cells expressed PDGFRA in intra-muscular spaces. These findings suggest that the enhance expression of HMGB2 induces the adipogenesis of MSCs and the fat infiltration into skeletal muscles through the cascade of HMGB2-PDGFRA.
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| Free Research Field |
整形外科学
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