Pathophysiological analysis of knee osteoarthritis targeted for synovium and its application for regulation of the disease

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10494
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Juntendo University
• Principal Investigator: ISHIJIMA Muneaki 順天堂大学, 医学(系)研究科(研究院), 准教授 (70365576)
• Co-Investigator(Renkei-kenkyūsha): KANEKO Kazuo 順天堂大学, 医学研究科, 教授 (50311981) ; HIRASAWA Eri 順天堂大学, 医学研究科, 教授 (50245718)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 変形性膝関節症 / 痛み / 滑膜 / 骨棘 / 半月板逸脱 / パールカン / 高位脛骨骨切り術 / 人工膝関節置換術

Outline of Final Research Achievements

We have examined the role of synovium for the pathophysiology of knee osteoarthritis (OA), while it has been mainly focused on the role of cartilage in this field. In the clinical research, we have revealed that synovitis, which is well corelated with clinical symptom of patients with knee OA, is associated with MRI-detected subchondral bone changes, but not cartilage damage, in patients with end-stage knee OA. We also have obtained by the basic research that perlecan in synovium plays a critical role for the regulation of Sox9 gene expression, which is a master gene for cartilage differentiation, in the synovial mesenchymal cells.

Free Research Field

変形性膝関節症の病態解明と効率的治療の実践