Pharmakocinetics of landiolol in patients undergoing cardiac surgery

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10502
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Asahikawa Medical College
• Principal Investigator: Kunisawa Takayuki 旭川医科大学, 医学部, 教授 (40339031)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 薬物動態 / 塩酸ランジオロール

Outline of Final Research Achievements

Measured concentrations of landiolol were similar to the predicted concentrations of landiolol calculated using parameters from patients undergoing vascular surgery. Although pharmacokinetic parameters of landiolol in healthy volunteers were smaller than those in patients undergoing cardiac surgery, there was no large difference. High sensitivity to landiolol in
high-risk patients are thought to be contributed to both pharmacodynamics (PD) and pharmacokinetics (PK), but the degree may be larger for PD than PK.

Free Research Field

心臓麻酔、経食道心エコー検査、静脈麻酔