The causes and measures of neural toxicity induced by inhalational anesthesia exposure on the developing brain

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10504
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Akita University
• Principal Investigator: Goyagi Toru 秋田大学, 医学部, 講師 (30302277)
• Co-Investigator(Kenkyū-buntansha): 木村 哲 秋田大学, 医学(系)研究科(研究院), 准教授 (00312702) ; 西川 俊昭 秋田大学, 医学(系)研究科(研究院), 教授 (50156048)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: anesthetic toxicity / preconditioning / neural apoptosis / developing brain / neural degeneration / neonatal brain

Outline of Final Research Achievements

Ii is well known that anesthetic exposure induces neural apoptosis and degeneration in neonatal immature brain, resulted in behavioral disorder and decline of learning ability after growth. We examined whether preconditioning (PC) with sevoflurane or hypoxia (10% oxygen) attenuated apoptosis and long-term neural degeneration in neonatal rats exposed to 3% sevoflurane. PC with 2% Sevoflurane or 10% oxygen before exposure to 3% Sevoflurane for 4 h would attenuate long-term cognitive dysfunction in neonatal rats. Moreover, PC of dexmedetomidine improved the spatial memory, and increased the normal cells in the brain 6 weeks after anesthesia exposure. These results indicated that PC is useful to ameliorate the neural toxicity induced by anesthetics in neonatal rats.

Free Research Field

麻酔科学、神経科学