Free radical scavenger edaravone produces robust neuroprotection in a rat model of spinal cord injury

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10505
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Niigata University
• Principal Investigator: ISHII Hideaki 新潟大学, 医歯学総合病院, 特任准教授 (60529775)
• Co-Investigator(Kenkyū-buntansha): 河野 達郎 東北医科薬科大学, 医学部, 教授 (00313536)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 脊髄損傷 / エダラボン

Outline of Final Research Achievements

We used multimodal approach to evaluate the effects of edaravone in a rat model of spinal cord injury (SCI). SCI was induced by extradural compression of the spinal cord at the thoracic level. Moderate-dose (3 mg/kg/h) edaravone was administered 30 min prior to compression, at the start of compression, or 10 min after decompression. Preemptive administration regimens resulted in significantly improved spinal motor-evoked potentials (MEPs). A moderate-dose of edaravone resulted in significant attenuation of lipid peroxidation, as evidenced by lower concentrations of free radical malonyldialdehyde (MDA) in the spinal cord at 3 h post-SCI. Both moderate- and high-dose edaravone resulted in significant functional improvements evidenced by better Basso-Beattie-Bresnahan (BBB) scores and better performance on the inclined plane during 8-wk period post-SCI.

Free Research Field

麻酔科学