Molecular biological study on action mechanism of general anesthetics

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10525
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Nippon Medical School
• Principal Investigator: Sakamoto Atsuhiro 日本医科大学, 大学院医学研究科, 大学院教授 (30196084)
• Research Collaborator: 森田 智教 日本医科大学, 大学院生 ; 大槻 達郎 日本医科大学, 大学院生 ; 木村 祐輔 日本医科大学, 大学院生 ; 藤本 彩子 日本医科大学, 大学院生 ; 松尾 いずみ 日本医科大学, 大学院生 ; 永本 盛嗣 日本医科大学, 大学院生 ; 岩崎 雅江 日本医科大学, 大学院生 ; 伊藤 直美 日本医科大学, 大学院生
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 全身麻酔薬 / 遺伝子発現 / microRNA / 虚血再潅流障害 / 全身炎症性反応 / 神経発達 / 日内変動

Outline of Final Research Achievements

The effects of general anesthetics themselves and the effects of general anesthetics at various disease states on the changes of internal gene expression, especially microRNA (miRNA) expression were evaluated. How these effects are related to gene expression (messenger RNA: mRNA), protein expression and metabolites affected by general anesthesia were also evaluated. The results obtained from examinations of several conditions such as anesthetic exposure on newborn rats, ischemia-reperfusion injury, systemic inflammatory response syndrome, provided the basic data of miRNA expression for the mechanism elucidation of the general anesthesia.

Free Research Field

麻酔科学