2017 Fiscal Year Final Research Report
Analysis of the NF-kB pathway in the initial immune response under inflammatory conditions
| Project/Area Number |
15K10530
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
後藤 薫 山形大学, 医学部, 教授 (30234975)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 炎症応答 / 脂質代謝酵素 / 転写活性 / 核内移行 / リン酸化 |
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| Outline of Final Research Achievements |
Transcription factor NFkB plays a central role in various signaling pathways including immune response, inflammation, cell survival and death, and cancer. In the present study, we examined how zeta isoform of diacylglycerol kinase (DGK) regulates NFkB pathway. We found that after TNF-alpha stimulation DGKzeta deficiency leads to facilitated nuclear transport of NFkB p65 subunit together with its enhanced phosphorylation, thereby upregulating NFkB transcriptional activity. These results suggest that DGKzeta negatively regulates NFkB pathway and that DGKzeta downregulation may enhance inflammatory response.
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| Free Research Field |
麻酔科学
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