The role of cellular redox system in inflammatory disorders of acute lung injury

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10551
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: The Tazuke Kofukai
• Principal Investigator: ADACHI Takehiko 公益財団法人田附興風会, 医学研究所 第9研究部, 部長 (90252428)
• Co-Investigator(Kenkyū-buntansha): 広田 喜一 関西医科大学, 医学部, 教授 (00283606)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 酸素環境 / 敗血症 / 急性肺障害 / thioredoxin / TXNIP / HIF-1

Outline of Final Research Achievements

The aim of this study is to evaluate the clinical significance of the cellular redox system consisting of thioredoxin and thioredoxin interacting protein (Txnip) for the protection against inflammatory disorders including septi shock, ALI, and ARDS. Since inflammation has been associated with hypoxia and the resulting dysregulation of oxygen homeostasis, we investigated the functional interaction between the thioredoxin system and hypoxia-inducible factor 1 (HIF-1) under inflammatory conditions. We showed that thioredoxin enhanced the transcriptional activity of HIF-1. Thioredoxin-induced HIF-1 activation up-regulated the expression level of Txnip, which could, in turn, suppress the function of thioredoxin. These results revealed that the cellular redox environment was maintained by a subtle balance and interplay between these redox-related molecules.

Free Research Field

麻酔科学