Management of adverse effects of of androgen deprivation therapy in Japanese patients with prostate cancer

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10571
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Tohoku University
• Principal Investigator: Mitsuzuka Koji 東北大学, 大学病院, 講師 (80568171)
• Co-Investigator(Kenkyū-buntansha): 安達 尚宣 東北大学, 医学系研究科, 大学院非常勤講師 (20706303) ; 荒井 陽一 東北大学, 医学系研究科, 教授 (50193058) ; 川崎 芳英 東北大学, 医学系研究科, 助教 (80722256)
• Research Collaborator: KYAN Atsushi ; SATO Tomonori ; ORIKASA Kazuhiko ; MIYAZATO Minoru ; AOKI Hiroshi ; NARITA Shintaro ; KOIE Takuya ; TOCHIGI Tatsuo ; HABUCHI Tomonori ; OHYAMA Chikara
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 脂質代謝 / ホルモン療法 / 前立腺癌

Outline of Final Research Achievements

Adverse events related to ADT are now well known among urologists and have been well studied, mainly in western countries. However, the influence of ADT may differ between races and regions. A few small studies described the effects of ADT on metabolism in Japanese patients with prostate cancer, but information with regard to ADT-related adverse events in Japanese patients is very sparse.
This study showed that one year of ADT increased body weight and altered lipid and glucose metabolism in Japanese patients with prostate cancer.Metabolic changes were particularly noted during the first 3-6 months of ADT therapy.CT measurements of fat accumulation revealed a significant increase in both visceral and subcutaneous fat, and the increase was greater in subcutaneous fat than in visceral fat. These results may be useful for patients who intend to undergo ADT.

Free Research Field

前立腺癌