Basic research for clinical application of new thermal therapy to inject magnetic nano-particles into cancer metastasis via IVR technology

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10602
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Nagoya City University
• Principal Investigator: Kawai Noriyasu 名古屋市立大学, 大学院医学研究科, 准教授 (20254279)
• Co-Investigator(Kenkyū-buntansha): 安藤 亮介 名古屋市立大学, 医学(系)研究科(研究院), その他 (30381867) ; 戸澤 啓一 名古屋市立大学, 大学院医学研究科, 教授 (40264733) ; 内木 拓 名古屋市立大学, 大学院医学研究科, 講師 (50551272) ; 小林 大地 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (80570704)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 温熱治療 / 磁性微粒子 / 交流電流 / IVR

Outline of Final Research Achievements

For the purpose of applying thermotherapy using magnetite and 8-MHz radio waves for the treatment of metastatic lesions of various solid cancers, we developed a method of injecting and stagnating magnetite into target organs using IVR technology. And we evaluated whether hyperthermia can treat these lesion with renal cancer model. Magnetite and Lipiodol blend were injected and the temperature of the same part was confirmed to rise with Thermotron RF-8. It was confirmed that it is possible to inject magnetite blend by ordinary IVR technology.
At this time, hyperthermia treatment using IVR technology could not be performed, but by summarizing the data, the utility of this research towards the clinical application of magnetic microparticles into cancer metastasis via IVR technology is shown.

Free Research Field

泌尿器系腫瘍