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2017 Fiscal Year Final Research Report

Analysis of newly detected serum protein and trial of establishment of diagnostic tool in patients with bladder cancer

Research Project

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Project/Area Number 15K10607
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionKitasato University

Principal Investigator

MATSUMOTO KAZUMASA  北里大学, 医学部, 准教授 (70306603)

Co-Investigator(Kenkyū-buntansha) 岩村 正嗣  北里大学, 医学部, 教授 (20176564)
佐藤 雄一  北里大学, 医療衛生学部, 教授 (30178793)
Project Period (FY) 2015-04-01 – 2018-03-31
Keywords膀胱癌 / 尿路上皮癌 / 蛋白質 / 抗体 / 腫瘍マーカー
Outline of Final Research Achievements

We investigated an association of clinicopathological factors with newly detected proteins which we found using proteomics analyses in patients with bladder cancer. For example, serum PPP1CA was higher in patients with bladder cancer than in healthy controls. In addition, high levels of serum PPP1CA was associated with muscle-invasive cancer, high grade, the status of lymphovascular invasion and poor prognosis. Using cisplatin resisted bladder cancer cell line, we identified 25 obviously different spots for naive bladder cancer cell line. Seven spots had increased expression and 18 spots had decreased expression in cisplatin-resisted cell compared to those in naive cell. We will plan to examine whether the rest of bladder specific and cisplatin-resisted proteins detected in this project would be matched in real world clinical scenario.

Free Research Field

泌尿器科学、腫瘍学

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Published: 2019-03-29  

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