2017 Fiscal Year Final Research Report
The ameliorative potential of tamsulosin on bladder function in an established rat model of chronic pelvic ischemia
| Project/Area Number |
15K10621
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KIRA Satoru 山梨大学, 大学院総合研究部, 助教 (10530115)
TAKEDA Masayuki 山梨大学, その他部局等, 理事 (80197318)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 慢性虚血 / 低活動膀胱 / α１阻害剤 |
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| Outline of Final Research Achievements |
The atherosclerotic obstructive changes will have consequences for the distal vasculature and LUTS blood flow.Recently overactive bladder is supposed to advance to underactive bladder due to ischemic insult.To mimic the elder LUTS patient,we delayed administering tamsulosin for 8 weeks from the establishment of chronic pelvic ischemia(CPI)rat model and checked the improving effect for voiding dysfunction.The animals treated with tamsulosin showed an improved bladder function presumably due to the increased bladder flow.If these results are valid for the bladder dysfunction in humans,they support that the treatment of tamsulosin will improve the elderly LUTS patients.
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| Free Research Field |
排尿機能、性機能、慢性虚血
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