Elucidation of the pathology of mitochondrial injury during urinary calculi formation and development of prevention.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10627
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Nagoya City University
• Principal Investigator: YASUI TAKAHIRO 名古屋市立大学, 大学院医学研究科, 教授 (40326153)
• Co-Investigator(Kenkyū-buntansha): 田口 和己 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (00595184) ; 郡 健二郎 名古屋市立大学, その他部局等, 学長 (30122047) ; 安藤 亮介 名古屋市立大学, 医学(系)研究科(研究院), その他 (30381867) ; 戸澤 啓一 名古屋市立大学, 大学院医学研究科, 教授 (40264733) ; 岡田 淳志 名古屋市立大学, 大学院医学研究科, 講師 (70444966) ; 濱本 周造 名古屋市立大学, 大学院医学研究科, 講師 (80551267)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 尿路結石 / 酸化ストレス / ミトコンドリア / マクロファージ

Outline of Final Research Achievements

(1) Development of medicine and biomarkers focusing on the mitochondrial injury of renal tubule cells.:The oxalic acid precursor was administered to the knockout mouse of Cyclophilin D (cypD), and the formation of stone and the molecular mechanism were elucidated. Compared to in wild-type, mitochondrial injury and stone formation were small in CypD knockout mice.
(2) Identification of new related genes and development of risk diagnosis method.:We tried to establish a diagnosis method of onset risk from the gene region identified by comprehensive human genome-wide association analysis. The related genes were examined using a multiplex analysis system. M1 macrophage-related substances decreased in healthy subjects and M2 macrophage-related substances decreased in stone patients.

Free Research Field

泌尿器科学